e. Linezolid (ZyvoxÒ)
Linezolid belongs to a new class of synthetic antimicrobials, the oxazolidinones. Linezolid has activity against Enterococcus faecium, Enterococcus faecalis, MSSA, MRSA, MRSE and many Streptococcal spp. Linezolid is available as an intravenous and oral preparation. After oral administration, linezolid is completely absorbed and has 100% bioavailability. Therefore, in patients tolerating oral medications linezolid will be administered orally [600 mg PO/IV BID] [Pediatrics: 10 mg/kg q8h PO/IV]
Criteria for use:
Linezolid cannot be released for the treatment of the following:
Consideration for use:
Acquired resistance to linezolid can occur during therapy (documented with VRE).
Linezolid's oral formulation is 100% bioavailable. Whenever possible patients should receive po voriconazole.
· Standard adult dose: 600mg po/IV q12h
Dosage adjustment is unneccessary in renal or hepatic insufficiency.
For approval of restricted antimicrobials contact ID pharmacy at 443-9421