Guidelines
Baddour LM, et al. Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: executive summary. Circulation 2005;111:3167-3184.
-Summary of updated American Heart Association guidelines for management of endocarditis. Covers most common causes of endocarditis. Considered the gold standard for therapy. Full (48 page) guidelines are also available online and in pdf.
Baddour LM, et al. Nonvalvular cardiovascular device-related infections. Circulation 2003;108:2015-2031.
-American Heart Association position paper on treatment of infections on nonvalvular prosthetic materials. Covers pacemaker/ICDs, LVADs, vascular grafts, stents, IABPs, vena caval filters, and more.
Reviews
Bayer AS, et al. Diagnosis and management of infective endocarditis and its complications. Circulation 1998;98:2936-2948.
-Diagnostic-focused review of endocarditis.
Brouqui P, et al. Endocarditis due to rare and fastidious bacteria. Clin Micro Rev 2001;14:177-207.
-Comprehensive review of "culture-negative" and unusual endocarditis.
Le T, et al. Combination antibiotic therapy for infective endocarditis. Clin Inf Dis 2003;36:615-621.
-Review of in vitro and in vivo evidence behind combination therapy in infective endocarditis. Table 1 summarizes available clinical trial data.
Mylonakis E, et al. Infective endocarditis in adults. N Eng J Med 2001;345:1318-1330.
-Overview of diagnosis and management of infective endocarditis.
Clinical Data
Sexton DJ, et al. Ceftriaxone once daily for four weeks compared with ceftriaxone plus gentamicin for two weeks for treatment of endocarditis due to penicillin-susceptible streptococci. Clin Inf Dis 1998;27:1470-1474.
-Randomized trial of 4 weeks of CTX 2g IV q24h vs. 2 weeks of CTX 2g IV q24h plus gentamicin 3 mg/kg IV q24h for treatment of uncomplicated native-valve endocarditis due to susceptible viridans streptococci in patients with normal renal function. Frequency of successful outcomes was high (>95%) and similar in both groups.