Summary of Antimicrobial Susceptibility

N/A-testing NOT APPLICABLE to organism. CZOL-cefazolin, CTRX-ceftriaxone, CTAZ-ceftazidime,

CFPM-cefepime, GEN-gentamicin, TOB-tobramycin, T/S-trimethoprim/sulfamethoxazole, CIP-ciprofloxacin,

IMI-imipenem, P/T-piperacillin-tazobactam, PCN-penicillin, NAF-nafcillin, ERY-erythromycin, CLIN-clindamycin,

Total isolates include Floor Isolates and ICU Isolates from UCSF and Mt. Zion Hospitals (Does not include Outpatient)

(Clicking on organism name will give comprehensive antibiogram and trending, if available)

Organism	Total Isolates	CZOL	CTRX	CTAZ	CFPM	GEN	TOB	T/S	CIP	P/T	MER
Acinetobacter baumannii	20	N/A	N/A	75	80	90	95	75	75	68	95
Citrobacter freundii	29	N/A	76	79	97	93	93	86	90	83	100
Enterobacter aerogenes	42	N/A	71	71	100	98	98	95	95	69	98
Enterobacter cloacae	75	N/A	65	64	97	89	91	76	91	68	100
Escherichia coli*	552	84	91	95	97	89	88	63	68	97	100
Klebsiella oxytoca	29	93	100	100	100	97	97	90	97	97	100
Klebsiella pneumoniae	148	91	95	95	99	97	96	82	94	90	100
Proteus mirabilis	51	90	98	96	98	90	88	82	86	100	100
Pseudomonas aeruginosa** ICU Non-ICU	181 59 125	N/A	N/A	93 86 95	94 88 97	90 88 90	94 88 97	N/A	80 83 76	94 89 97	89 83 91
Serratia marcescens	42	N/A	98	100	100	98	95	98	98	95	100

** note Pseudomonas aeruginosa isolates do not include isolates from cystic fibrosis patients

¨ *Escherichia coli Outpatient TMP/SMX susceptibility is 68%. Outpatient ciprofloxacin susceptibility

is 78%. Nitrofurantoin susceptibility is 97% and should only be used for uncomplicated

UTIs in patients with CrCl>60ml/min. Outpatient cefazolin susceptibility is 92%.

¨ Haemophilus influenzae National incidence of b-lactamase production is 37%

¨ Stenotrophomonas maltophilia Routine antimicrobial susceptibility testing is performed on sterile sites. TMP/SMX

is the most active agent versus this organism. Contact ID or ID pharmacy for alternatives.

Total isolates include Floor Isolates and ICU Isolates from UCSF and Mt. Zion Hospitals (Does not include Outpatient)

(Clicking on organism name will give comprehensive antibiogram and trending, if available)

Organism	Total Isolates	PCN	NAF	ERY	CLIN	CIP	DOX	T/S	VANC
Staphylococcus aureus* MRSA MSSA	450 176 274	14	61	46 9 70	69 41 86	57 50 60	91 90 91	97 94 99	100
Staphylococcus epidermidis	236	8	35	35	64	42	77	53	100
Streptococcus pneumoniae†	51	See below	N/A	76	84	N/A	80	67	100

¨ *Staphylococcus aureus Outpatient Nafcillin susceptibility 70%. (Nafcillin resistance predicts cephalosporin resistance)

¨ Enterococcus species Enterococcus faecalis species are 100% AMP susceptible. Enterococcus faecium can be multi-drug resistant. Check vancomycin susceptibilities for all isolates from sterile sites. The addition of gentamicin (1 mg/kg Q8h) is required for bactericidal activity in serious systemic enterococcal infections.

Of 89 enterococcal bacteremias in 2010, 66 were due to Enterococcus faecium. 59 (89%) of the Enterococcus faecium were vancomycin resistant.

¨ Streptococcus pneumoniae 27% (12/43 isolates) were penicillin non-susceptible. All isolates were levofloxacin-susceptible. 5/25 isolates were CTX intermediate (3/25 were CTX resistant). NOTE: For the treatment of meningitis, pending susceptibilities, VANC empirically should be added to the regimen since failures (due to highly resistant isolates) have been reported with ALL third generation cephalosporins

¨ Anaerobes Routine antimicrobial susceptibility is not performed; results are not reproducible. B. fragilis group universally produced β-lactamase. Metronidazole, piperacillin/tazobactam, imipenem, meropenem all cover >98% of anaerobes.