Summary of Antimicrobial Susceptibility

N/A-testing NOT APPLICABLE to organism. CZOL-cefazolin, CTRX-ceftriaxone, CTAZ-ceftazidime,

CFPM-cefepime, GEN-gentamicin, TOB-tobramycin, T/S-trimethoprim/sulfamethoxazole, CIP-ciprofloxacin,

IMI-imipenem, P/T-piperacillin-tazobactam, PCN-penicillin, NAF-nafcillin, ERY-erythromycin, CLIN-clindamycin,

Total isolates include Floor Isolates and ICU Isolates from UCSF and Mt. Zion Hospitals (Does not include Outpatient)

(Clicking on organism name will give comprehensive antibiogram and trending, if available)

Organism	Total Isolates	CZOL	CTRX	CTAZ	CFPM	GEN	TOB	T/S	CIP	P/T	IMI
Acinetobacter baumannii	33	N/A	N/A	33	39	67	88	51	33	N/A	93
Citrobacter freundii	30	N/A	77	70	97	97	90	77	77	77	100
Enterobacter aerogenes	38	N/A	71	68	100	100	100	97	87	71	95
Enterobacter cloacae	96	N/A	66	68	89	92	91	76	85	70	99
Escherichia coli*	637	72	85	88	88	80	77	60	63	91	100
Klebsiella oxytoca	43	54	91	95	100	95	100	93	98	93	100
Klebsiella pneumoniae	181	91	93	94	97	93	93	82	87	92	99
Proteus mirabilis	67	79	100	100	100	91	91	76	78	100	100
Pseudomonas aeruginosa**	254	N/A	N/A	82	79	86	95	N/A	62	90	78
Serratia marcescens	35	N/A	94	97	97	97	94	94	89	91	100

** note Pseudomonas aeruginosa isolates do not include isolates from cystic fibrosis patients

¨ *Escherichia coli Outpatient TMP/SMX susceptibility is 70%. Outpatient ciprofloxacin susceptibility

is 78%. Nitrofurantoin susceptibility is 97% and should only be used for uncomplicated

UTIs in patients with CrCl>60ml/min. Outpatient cefazolin susceptibility is 87%.

¨ Haemophilus influenzae National incidence of b-lactamase production is 37%

¨ Stenotrophomonas maltophilia Routine antimicrobial susceptibility testing is performed on sterile sites. TMP/SMX

is the most active agent versus this organism. Contact ID or ID pharmacy for alternatives.

Total isolates include Floor Isolates and ICU Isolates from UCSF and Mt. Zion Hospitals (Does not include Outpatient)

(Clicking on organism name will give comprehensive antibiogram and trending, if available)

Organism	Total Isolates	PCN	NAF	ERY	CLIN	CIP	DOX	T/S	VANC
Staphylococcus aureus*	595	13	53	37	58	56	98	98	100
Coagulase-negative Staphylococci	355	8	27	33	60	33	88	54	100
Streptococcus pneumoniae†	70	See below	N/A	80	N/A	N/A	83	77	100

¨ *Staphylococcus aureus Outpatient Nafcillin susceptibility 66%. (Nafcillin resistance predicts cephalosporin resistance)

¨ Enterococcus species Enterococcus faecalis is 100% AMP susceptible. Enterococcus faecium can be multi-drug resistant. Check vancomycin susceptibilities for all isolates from sterile sites. The addition of gentamicin (1 mg/kg Q8h) is required for bactericidal activity in serious systemic enterococcal infections. Of 110 enterococcal bacteremias in 2008, 57 were due to Enterococcus faecium. 95% of the Enterococcus faecium were vancomycin resistant. Of the 54 VRE blood isolates in 2008, all were linezolid susceptible.

¨ Streptococcus pneumoniae 29% (20/70 isolates) were penicillin non-susceptible. 3 isolates were levofloxacin-resistant and 1 was intermediate to levofloxacin. 2/31 isolates were CTX resistant. NOTE: For the treatment of meningitis, pending susceptibilities, VANC empirically should be added to the regimen since failures (due to highly resistant isolates) have been reported with ALL third generation cephalosporins

¨ Anaerobes Routine antimicrobial susceptibility is not performed; results are not reproducible. B. fragilis group universally produced β-lactamase. Metronidazole, piperacillin/tazobactam, imipenem, meropenem all cover >98% of anaerobes.