Diagnosis

Common

Pathogens

Drug(s) of

First Choice¹

Alternative

Drug(s)¹

Comments

LINE-RELATED INFECTIONS

Line-related bacteremia

(+ peripheral blood culture)

Staph. epidermidis

Staph. aureus

Yeast

Enterococci

Occasional gram negative rods

Vancomycin²

WITH OR WITHOUT* one of:

Piperacillin/tazobactam⁶ (Zosyn)

4.5g IV q8h

OR

Cefepime⁵ 2g IV q12h

Vancomycin²  

WITH OR WITHOUT* one of:

Aztreonam⁶  2g q8h

OR

Gentamicin²

Remove the offending intravascular device immediately, if possible.

*Consider Gram-negative coverage for immunocompromised patients or those with prolonged hospitalization, recent antibiotic exposure or sepsis