Diagnosis

Common

Pathogens

Drug(s) of

First Choice1

Alternative

Drug(s)1

Comments

DIVERTICULITIS

No signs of bowel perforation.

 

If bowel perforation, see Peritonitis on Inpatient Antibiotic Guidelines

 

 

Enterobacteriaceae

Bacteroides fragilis

Enterococci

Amoxicillin/

clavulanate

875mg/125mg PO BID

OR

Moxifloxacin5,6 400mg PO daily

 

Duration of treatment should be until patient is afebrile for 3-5 days

For severe PCN allergy3:

Metronidazole 500mg PO q8h

Plus one of:

Ciprofloxacin 500mg PO q12h

OR

Levofloxacin5 500mg PO daily

 

Duration of treatment should be until patient is afebrile for 3-5 days

 

Surgical evaluation and follow up is advised.